Urea - močovina

27.7.2012

urea.jpg - kopie
urea.jpg - kopie
Urea - močovina - je jakýsi univerzální produkt odpadního metabolismu. Játra přijímají různé odpadní látky a vyrábí z nich právě močovinu. Močovina je potom z jater vypuzena do krve a unášena do ledvin, kterými je odstraněna z organismu pryč. Zvýšená hladina močoviny tak ukazuje na poškození ledvin...

Urea

Močovina (urea) je v lidském organismu nejvýrazněji spojena se dvěma orgány, játry a ledvinami. Játra jsou mohutným orgánem, bohatě prokrveným, zavěšeným pod pravou brániční klenbou. Jaterní buňka je místem, kde probíhá mnoho různých chemických reakcí. Mezi ně patří například zpracovávání živin, výroba a inaktivace hormonů, tvorba žluči, odstraňování toxických látek z krve, tvorba látek zajišťujících srážení krve, zásobní funkce a mnoho jiných. Ledviny také produkují hormony a látky důležité pro správnou funkci těla, ale jejich hlavní funkcí je definitivní odstraňování nepotřebných a škodlivých látek močí. Mezi tyto látky patří i močovina.

Urea a její koloběh

Při mnohých chemických reakcích v buňkách lidského těla vznikají nebezpečné sloučeniny dusíku. Těchto nebezpečných dusíkových sloučenin se musíme zbavit. Těchto látek se nejprve ujmou játra a vytvoří z nich močovinu. Močovinu vypustí zpět do oběhu, kde je unášená krví. Z krve si močovinu vychytají ledviny, které ji systémem složitých ledvinných kanálků přefiltrují do moči a vyloučí ji tak z organismu. Můžeme si snadno představit, že jestliže ledviny nefungují tak, jak mají, nejsou schopny močovinu odstraňovat a ta zůstává v krvi. Močovina je tedy sledována vždy při podezření na ledvinné selhání, při hospitalizace pacienta, jestliže je pacient léčen diuretiky (léky podporující močení) i jako při běžném vyšetření krve.

Urea a změny její hladiny

Snížení hladiny močoviny v krvi není problémem. Naopak zvýšení koncentrace v krvi je varovným znamením, že něco není v pořádku. Obecně lze říci, že čím vyšší je množství močoviny v krvi, tím závažnější bude postižení ledvin. Ledviny nezvládají filtrovat krev a zbavovat organismus močoviny, která přebývá v krvi. Společně s močovinou je nahlíženo i na hodnoty kreatininu, který se z hlediska posouzení funkčnosti ledvin chová naprosto stejně jako močovina. Příčinou může být akutní nebo chronická choroba ledvin, jejich poškození nebo selhání. Podobné příznaky vyvolá i snížení množství krve, které ledvinami proteče. To může mít více příčin. Jedná se například o městnání krve z důvodu srdečního selhání, šok, stres a o stavy, které jsou spojeny se ztrátou tekutin, tedy popáleniny a krvácení. Dále je to překážka v odtoku moči, například močové kameny v močovodu. Jinou možností může být zúžení ledvinné tepny, která přivádí krev. Zúžení je nejčastěji způsobeno ukládáním tuku do stěny cévy, tedy aterosklerózou. Rizikovými faktory pro rozvoj aterosklerózy jsou vysoký věk, kouření, vyšší množství cholesterolu, vysoký krevní tlak, pohlaví (muži častěji) a genetická výbava. Zvýšené množství močoviny může být také výsledkem nadměrné konzumace bílkovin.

Urea a vyšetření

Močovina se tedy používá jako ukazatel funkce ledvin. Používá se na kontrolní monitorování zdravotního stavu u pacientů, u kterých je onemocnění známo, ale je i součástí běžného rutinního vyšetření krve. Pro vyšetření postačuje pouze malý vzorek krve, která se odebírá téměř bezbolestným způsobem z pažní žíly. Každý to jistě zná a byl někdy „na krvi". Přesto není radno zvýšenou hladinu močoviny v krvi podceňovat, protože svědčí o onemocnění ledvin, které může mít velmi závažné důsledky.

 

Močovina (krev)
Muži: 2,8 – 8 mmol/L
Ženy: 2 – 6,7 mmol/L

 

 

Močovina (moč) 167-583 mmol/L za 24hod bez ohledu na pohlaví

 

 

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